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KMID : 0359020100400010027
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Korean Journal of Gastrointestinal Endoscopy
2010 Volume.40 No. 1 p.27 ~ p.30
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A Case of Gastric Adenocarcinoma in a Patient with X-linked Agammaglobulinemia
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Ok Chang-Soo
Lee Jun-Haeng
Noh Jung-Won
Sohn Seo-Young
Chang Bok-Soon
Ku Bon-Ho
Koh Won-Jung
Sung Chang-Ohk
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Abstract
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X-linked agammaglobulinemia is a common type of primary immunodeficiency disorder that’s caused by mutation of the BTK gene. The absence of B lymphocytes and plasma cells causes recurrent infections. Patients with X-linked agammaglobulinemia also have a high risk for developing hematological malignancies and, to a lesser degree, carcinoma. We report here on a 26-years-old male patient who suffered with X-linked agammaglobulinemia that was caused by BTK gene mutation, and he developed a gastric cancer in the antrum. He was noted to have chronic atrophic gastritis and diffuse intestinal metaplasia on the endoscopic examination that was done 7 years previously. We recommend regular esophagogastroduodenoscopic evaluation for a patient with X-linked agammaglobulinemia in order to make an early diagnosis of stomach carcinoma.
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KEYWORD
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X-linked agammaglobulinemia, Stomach cancer
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